B8271
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B8271
Sigma
Bromoacetic acid N-hydroxysuccinimide ester
~95%, powder
| CAS Number: | 42014-51-7 |
| Linear Formula: | C6H6BrNO4 |
| Molecular Weight: | 236.02 |
| MDL number: | MFCD00058571 |
| PubChem Substance ID: | 24892067 |
Description
| Application | A heterobifunctional cross-linking reagent which allows bromoacetylation of primary amine groups followed by coupling to sulfhydryl-containing compounds. Typically, initial reaction couples via ester to primary amine by amide bond formation in the pH range 6.5-8.5. The second reaction results in thioether bonding in pH range 7.0-8.0. |
| Caution | The bromoacetyl group is light sensitive. |
Properties
| assay | ~95% |
| form | powder |
| solubility | acetone: 25 mg/mL |
| DMF: soluble | |
| shipped in | dry ice |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Gloves |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
References
| reference | Bernatowicz, M.S. and Matsueda, G.R., Preparation of peptide-protein immunogens using N-succinimidyl bromoacetate as a heterobifunctional crosslinking reagent. Anal. Biochem. 155, 95-102, (1986) Abstract |
